| 000 -LEADER |
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| fixed length control field |
03868nam a22002417a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
180912s2018 ua ||||g b||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
SOUL |
| 041 ## - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
ara |
| Language code of original |
eng |
| 082 40 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Edition number |
21 |
| Classification number |
615 |
| Item number |
E M |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
4487 |
| Personal name |
Mostafa, Shorouk Mohamed |
| 245 01 - TITLE STATEMENT |
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| Title |
EFFECT OF MANGIFERIN ON MULTIPLE ORGAN DYSFUNCTION SYNDROME INDUCED BY INTESTINAL ISCHEMIA/REPERFUSION IN RATS / |
| Statement of responsibility, etc. |
Shorouk Mohamed Mostafa ; Supervised by Hanan Salah El-Din El-Abhar, Azza Sayed M. Awad. |
| 246 03 - VARYING FORM OF TITLE |
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| Title proper/short title |
تأثير المانجفيرين في متلازمة قصور وظائف الأعضاء المتعددة المحدث بسبب حبس وإعادة التروية الدموية في الأمعاء الدقيقة في الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Place of publication, distribution, etc. |
Cairo University |
| Name of publisher, distributor, etc. |
Faculty of Pharmacy |
| Date of publication, distribution, etc. |
2018. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
xv, 3, 227 p. : |
| Other physical details |
ill. : |
| Dimensions |
24 CM. |
| Accompanying material |
+CD |
| 500 ## - GENERAL NOTE |
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| General note |
Thesis (Ph.D.) – Cairo University. Faculty of Pharmacy. Department of Pharmacology & Toxicology.
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| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc |
Includes bibliographical references. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Aim: Mangiferin (MF), a xanthonoid from Mangifera indica, possesses anti-inflammatory, immunomodulatory, and potent antioxidant effects; however, its protective effect against multiple organ dysfunction syndrome has not been fully clarified. The study was designed to assess the possible mechanism of action of MF20 and its nano-formulation (NMF10) against mesenteric I/R model. Main Methods: Male Wister rats were randomly allocated into 6 groups (n= 6); in the first group, rats received saline and the SMA was manipulated only to serve as the sham-operated group. In the 5 other groups rats were subjected to I/R, which was induced by clamping the superior mesenteric artery for 30 minutes followed by declamping for 60 minutes. group 2 was donated as the untreated I/R control and animals received saline only, while in groups 3 and 4, animals were pre-treated with MF (20 mg/kg, i.p) or NMF (10mg/kg, i.p), for 3 days before I/R, while rats in groups 5 and 6 received the two blockers; viz., methyllycaconitine (MLA) and atropine (Sigma-Aldrich Chemical Company, MO, USA) 30 min before NMF10 for 3 days. MF20 was dissolved in the vehicle (2% DMSO in saline), while NMF10 were sonicated well before administration. Atropine and methyllycaconitine (MLA) were diluted with 0.9% saline prior to the experiment. Key findings: The mechanistic studies revealed that MF20 protected the 3 organs studied, viz., liver, kidney and intestine partly via increasing the content of β-catenin and PPAR-γ along with decreasing that of GSK-3β and the phosphorylated NF-қB-p65. MF20 and NMF10 antioxidant effect was evidenced by increasing contents of total antioxidant capacity and GST, besides normalizing that of MDA and increasing m-RNA levels of NRF-2 and HO-1. Regarding the anti-inflammatory effect, MF20 reduced IL-1β and IL-6, effects that were mirrored on the tissue contents of MPO and MMP-9. Moreover, MF20 and NMF10 possessed anti-apoptotic character evidenced by elevating Bcl-2 content and reducing that of caspase-3. In the serum, intestinal I/R increased the activity of ALT, AST, creatinine, and creatine kinase. In all the measured parameters, NMF10 showed promise over MF20, however, these protective effects were deterred by the presence of atropine but not MLA. Significance: The intimated protective mechanisms of MF20 and NMF10 against MODS progression are mediated, partially, by modulation of oxidative stress, inflammation, and apoptosis possibly via the involvement of Wnt/β-catenin/NF-қβ/ PPAR-γ and NRF-2/HO-1 signaling pathways with contribution of muscarinic receptors.
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| 546 ## - LANGUAGE NOTE |
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| Language note |
Text in English, abstracts in English and Arabic.
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| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4488 |
| Topical term or geographic name as entry element |
Pharmacology & toxicology. |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
4489 |
| Personal name |
Awad, Azza Sayed M. |
| Relator term |
Supervisor |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
4490 |
| Personal name |
El-Abhar, Hanan Salah El-Din, |
| Relator term |
Supervisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
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| Koha item type |
Theses |
| Item part |
Faculty of Pharmacy كلية الصيدلة |
