| 000 -LEADER |
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| fixed length control field |
03049nam a22002177a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
180912s2017 ua ||||g b||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
SOUL |
| 041 ## - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
ara |
| Language code of original |
eng |
| 082 40 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Edition number |
21 |
| Classification number |
572 |
| Item number |
M P |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
4526 |
| Personal name |
William, Mira Magdy. |
| 245 01 - TITLE STATEMENT |
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| Title |
Potential Protective Effects of Avocado Extract (Persea americana) Against Some Chemotherapeutic Agents / |
| Statement of responsibility, etc. |
Mira Magdy William ; Supervised by Tarek M. K. Motawi, Hanan M. Abdelgawad, Mohammed M. Nooh. |
| 246 03 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
الآثار الوقائية المحتملة لمستخلص الأفوكادو ضد بعض عقاقير العلاج الكيميائي |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Cairo University |
| Date of publication, distribution, etc. |
2017. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
vii, 3, 159 p. : |
| Dimensions |
25 cm. |
| Accompanying material |
+CD |
| 500 ## - GENERAL NOTE |
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| General note |
Thesis (M.Sc.) – Cairo University. Faculty of Pharmacy. Department of Biochemistry.
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| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc |
Includes bibliographical references. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Use of cyclophosphamide (CPA) or fludarabine as chemotherapeutic agents is associated with deleterious side effects including pulmonary toxicity and urotoxicity or myelosuppression, respectively. Avocado, Persea americana Mill. is a widely consumed fruit in many countries for its nutritional and medicinal benefits. In the present study, we investigated the modulating effect of avocado fruit extract (AE) on some metabolizing enzymes involved in the activation and detoxification of CPA and fludarabine. Three phases of CPA-induced urotoxicity and pulmonary toxicity were studied; 2, 7 and 28 days after a single i.p. injection at a dose of 150 mg/kg. Fludarabine was injected (5 mg/kg/day, i.p.) for five consecutive days and tested for its myelosuppression 12 days post first injection. Cyclophosphamide induced acute elevation followed by late reduction in cytochrome P450 2B6 (CYP2B6) level in hepatic microsomes and significantly suppressed bladder and lung glutathione-S-transferase (GST) activity. Furthermore, CPA elevated bladder blood content, lung myeloperoxidase activity, DNA and hydroxyproline contents. Fludarabine produced a significant decrease in deoxycytidine kinase (dCK) and cytosolic nucleotidase II (cN-II) levels. In addition, fludarabine administration reduced total leukocytic and lymphocytic count as well as DNA polymerase and ribonucleotide reductase levels. Avocado extract administration (900 mg/kg/day p.o.) for 7 days prior to CPA and fludarabine exposure and its continuation for 2, 7 and 28 days post CPA and 12 days post first fludarabine injection, ameliorated all CPA and fludarabine induced derangements in spite of variable effects on metabolizing enzymes. Avocado extract administration suppressed CYP2B6 level, augmented GST activity of CPA treated rats and restored the level of both dCK and cN-II of fludarabine treated rats. In conclusion, these results show that AE plays a protective role against CPA and fludarabine-induced toxicity by regulating drug metabolizing enzymes and exerting antioxidant activity.
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| 650 40 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
1617 |
| Topical term or geographic name as entry element |
Biochemistry. |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
4527 |
| Personal name |
Nooh, Mohammed M. |
| Relator term |
Supervisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
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| Koha item type |
Theses |
| Item part |
Faculty of Pharmacy كلية الصيدلة |
