| 000 -LEADER |
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| fixed length control field |
02965nam a22002297a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
180912s2018 ua ||||g b||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Transcribing agency |
SOUL |
| 041 ## - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
ara |
| Language code of original |
eng |
| 082 40 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Edition number |
21 |
| Classification number |
615 |
| Item number |
A P |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
4546 |
| Personal name |
Ahmed, Sarah Ahmed Abd El-Aal. |
| 245 01 - TITLE STATEMENT |
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| Title |
The Potential Modulatory Effect of an inhibitor ofHMG-Coa Reductase Enzyme on Hippocampal Neuronal Damage Induced by Transient Global Cerebral Ischemia in Rats /
|
| Statement of responsibility, etc. |
Sarah Ahmed Abd El-Aal Ahmed ; Supervised by Hanan Salah El-Din El-Abhar, Mai Ahmed Galal. |
| 246 03 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
التأثير المعدل المحتمل لأحد مثبطى نشاط إنزيم (HMG-CoA reductase) فى تلف خلايا قرن آمون العصبية الناتج عن إحتباس الدم الشامل المؤقت فى مخ الجرذان. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Cairo University |
| Date of publication, distribution, etc. |
2018. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
xvii, 5, 200 p. : |
| Dimensions |
27 cm. |
| Accompanying material |
+CD |
| 500 ## - GENERAL NOTE |
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| General note |
Thesis (Ph.D.) – Cairo University. Faculty of Pharmacy. Department of Pharmacology & Toxicology.
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| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc |
Includes bibliographical references.
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| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Statins were reported to lower the CoQ10 content upon their inhibition of HMG-CoA reductase enzyme and both are known to possess neuroprotective potentials; therefore, the aim is to assess the possible use of CoQ10 as an adds-on therapy to rosuvastatin to improve its effect using global I/R model. Rats were allocated into sham, I/R, rosuvastatin (10 mg/kg), CoQ10 (10mg/kg) and their combination. Drugs were administered orally for 7 days before I/R. Pretreatment with rosuvastatin and/or CoQ10 inhibited the hippocampal content of MDA, NO and boosted GSH and SOD. They also opposed the up-regulation of gp91phox, and p47phox subunits of NADPH oxidase. Meanwhile, both agents reduced content/expression of TNF-α, iNOS, NF-κBp65, ICAM-1 and MPO. Besides, all regimens abated cytochrome c, caspase-3 and Bax, but increased Bcl-2 in favor of cell survival. On the molecular level, they increased p-Akt and its downstream target p-FOXO3A, with the inhibition of the nuclear content of FOXO3A to downregulate the expression of Bim, a pro-apoptotic gene. Additionally, both treatments downregulate the JNK3/c-Jun signaling pathway. The effect of the combination regimen overrides that of either treatment alone. These effects were reflected on the alleviation of the hippocampal damage in CA1 region inflicted by I/R. Together, these findings accentuate the neuroprotective potentials of both treatments against global I/R by virtue of their rigorous multi-pronged actions, including suppression of hippocampal oxidative stress, inflammation, and apoptosis with the involvement of the Akt/FOXO3A/Bim and JNK3/c-Jun/Bax signaling pathways. The study also nominates CoQ10 as an adds-on therapy with statins.
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| 546 ## - LANGUAGE NOTE |
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| Language note |
Text in English, abstracts in English and Arabic.
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| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
2548 |
| Topical term or geographic name as entry element |
Pharmacology, Clinical |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
4547 |
| Personal name |
Galal, Mai Ahmed, |
| Relator term |
Supervisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
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| Koha item type |
Theses |
| Item part |
Faculty of Pharmacy كلية الصيدلة |
