Design, Synthesis and Molecular Modeling Study of Some Thiazolidinone Derivatives as NS5B Polymerase inhibitors / (Titelsatznr. 59351)
[ MARC ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02116nam a22002417a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180912s2018 ua a|||g bm|| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | SOUL |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Edition number | 21 |
| Classification number | 615.1 |
| Item number | R D |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 4566 |
| Personal name | Ragab, Esraa Zakaria Mohammed |
| 245 10 - TITLE STATEMENT | |
| Title | Design, Synthesis and Molecular Modeling Study of Some Thiazolidinone Derivatives as NS5B Polymerase inhibitors / |
| Statement of responsibility, etc. | Esraa Zakaria Mohammed Ragab ; Supervised by Farghaly Abd-El Hamed Omar, Ghaneya Sayed Hassan, Hanan Hanna Georgey. |
| 246 01 - VARYING FORM OF TITLE | |
| Title proper/short title | تصميم وتشييد ودراسة النمذجة الجزيئية لبعض مشتقات الثيازوليدينون كمثبطات لإنزيم البوليمريز |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Cairo University, |
| Date of publication, distribution, etc. | 2018. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 182p. : |
| Other physical details | ill. ; |
| Dimensions | 26 cm. |
| Accompanying material | +CD. |
| 500 ## - GENERAL NOTE | |
| General note | Thesis (M.Sc.) – Cairo University. Faculty of Pharmacy. Department of Pharmaceutical Chemistry. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc | Includes bibliographical references. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | ) Hepatitis C virus (HCV) infection is a major global health challenge; it is estimated that more than 80 million people are chronically infected worldwide, 3–4 million new infections and 350 000 deaths occurring each year because of HCV-related complications. This thesis deals with the design and synthesis of some thiazolidinone derivatives to be evaluated as HCV-NS5B polymerase allosteric inhibitors. In addition, the anti-HCV activity was carried out for the new derivatives using a highly permissive subclone of the human hepatoma cell line Huh-7.5. Molecular docking studies were carried out to predict the possible binding mode of the newly synthesized compounds with HCV-NS5B polymerase to study their interaction with the enzyme key amino acids in a trial to explain their observed activity. Furthermore, key molecular characteristics were calculated to assess their drug-likeness potentia |
| 546 ## - LANGUAGE NOTE | |
| Language note | Text in English, abstracts in English and Arabic. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 3833 |
| Topical term or geographic name as entry element | Chemistry, Pharmaceutical |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 4568 |
| Personal name | Georgey, Hanan Hanna |
| Relator term | Supervisor |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 4569 |
| Personal name | Hassan, Ghaneya Sayed |
| Relator term | Supervisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Theses |
| Item part | Faculty of Pharmacy كلية الصيدلة |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection code | Permanent location | Current location | Shelving location | Date acquired | Full call number | Barcode | Date last seen | Copy number | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Default | 6october | 6october | 1208 | 2018-12-17 | 615.1 R D | SOULE208TH0800 | 2021-08-25 | 1 | 2018-12-17 | Theses |