Modulation Of Some Renal Pathological Consequences In Type-2 Diabetic Rats By A Glucagon-Like Peptide Receptor Agonis / (Titelsatznr. 59426)
[ MARC ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03149nam a22002417a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 181226s2016 ua a|||g bm|| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | SOUL |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | ara |
| Language code of original | eng |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Edition number | 21 |
| Classification number | 572 |
| Item number | I M |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 4820 |
| Personal name | Ibrahim, Shaymaa Galal. |
| 245 10 - TITLE STATEMENT | |
| Title | Modulation Of Some Renal Pathological Consequences In Type-2 Diabetic Rats By A Glucagon-Like Peptide Receptor Agonis / |
| Statement of responsibility, etc. | Shaymaa Galal Ibrahim ; Supervised by Tarek K. Motawi, Hanan M. Abd El-Gawad, Sherine Maher Rizk. |
| 246 03 - VARYING FORM OF TITLE | |
| Title proper/short title | تعديل بعض التبعات المرضية الكلوية في مرض السكرى النوع الثانى في الجرذان بواسطة ناهض لمستقبلات الببتيد شبيه الجلوكاجون |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Cairo University. Faculty of Pharmacy. Department of Biochemistry |
| Date of publication, distribution, etc. | 2016.. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | x, 4, 204p. : |
| Other physical details | ill. ; |
| Dimensions | 27 cm + |
| Accompanying material | 1 CD. |
| 500 ## - GENERAL NOTE | |
| General note | Thesis (M.Sc.) – Cairo University. Faculty of Pharmacy. Department of Biochemistry. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc | Includes bibliographical references. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Diabetic nephropathy (DN) is one of the most serious complications of diabetes mellitus. Our study aims to demonstrate the effectiveness of exenatide, glucagon like peptide-1 receptor agonist, on insulin release and renal functions in type 2 diabetes mellitus (T2DM) rats enduring DN. T2DM was induced by single streptozotocin (STZ) injection (40 mg/kg, i.p.) followed by high fat diet (HFD) for 10 weeks. Male wistar-albino rats were randomly divided into three groups: a normal control group, a HFD-STZ induced DN model group, and a DN plus exenatide (10 µg/kg/day, i.p.) treatment group. Animals were monitored by periodic biochemical testing of fasting serum glucose (FSG), cystatin-C, creatinine and urinary protein levels. At the end of the study (10 weeks) serum total nitrite/nitrate (NOx), adiponectin, C-peptide and amylase activity were investigated. Renal total triglycerides; hydroxy proline (HP), and DNA fragmentation were estimated, as well as renal enzymatic activity and mRNA expression level of glucose-6-phosphatase. Exenatide showed significant reduction in FSG, serum creatinine, cystatin- C, and urinary protein levels in diabetic rats. It favored increased serum NOx, serum adiponectin as well as C-peptide which reflects improving in insulin sensitivity and release respectively. Further, exenatide diminished renal DNA fragmentation, decreased renal triglyceride, HP contents, and glucose-6-phosphatase enzyme activity and expression levels in diabetic rats. Our data donate further credence for the effectiveness of exenatide against diabetic renal complications, through different aspects including reduction of renal DNA fragmentation and gluconeogenesis in addition to the previously reported mechanisms. Keywords: Diabetic nephropahy; exenatide; streptozotocin; high fat diet; gluconeogenesis; apoptosis. |
| 546 ## - LANGUAGE NOTE | |
| Language note | Text in English, abstracts in English and Arabic. |
| 650 40 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 1617 |
| Topical term or geographic name as entry element | Biochemistry. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 4821 |
| Personal name | Rizk, Sherine Maher, |
| Relator term | supervisor |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Cairo University. |
| Subordinate unit | Faculty of Pharmacy. |
| -- | Department of Biochemistry. |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Theses |
| Item part | Faculty of Medicine كلية الطب |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent location | Current location | Shelving location | Date acquired | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6october | 6october | 1208 | 2019-01-02 | 572 I M | SOULE208TH0783 | 2021-08-25 | 2019-01-02 | Theses |