Lectures presented at the 7th RSC Medicinal Chemistry School held June 28th-July 3rd 1993, at the University of Kent, Canterbury, UK.--Cf. pref.

Includes bibliographical references and subject index.

Ch. 1. An Introduction to Drug-Receptor Interactions / Barry Hunt -- Ch. 2. Signal Transduction and Second Messengers / Trevor J. Franklin -- Ch. 3. Enzyme Inhibitors / David A. Roberts -- Ch. 4. The Biological Evaluation of New Compounds / Robert A. Coleman -- Ch. 5. Pharmacokinetics / Robert M. J. Ings -- Ch. 6. Drug Metabolism / Colin Vose -- Ch. 7. Physicochemical Properties and Drug Design / Nigel P. Gensmantel -- Ch. 8. Quantitative Structure - Activity Relationships / Andrew M. Davis -- Ch. 9. Considerations for the Use of Computational Chemistry Techniques by Medicinal Chemists / Mike M. Hann -- Ch. 10. 'Patent Medicine' / Bill Tyrrell -- Ch. 11. Molecular Biology - A New Route to Drug Discovery / Janet E. Carey -- Ch. 12. Devising a Research Strategy / Colin W. Greengrass -- Ch. 13. Past Approaches to Discovering New Drugs as Medicines / C. Robin Ganellin.

Ch. 14. Bioisosteres, Conformational Restriction and Pro-drugs: Approaches to Lead Optimisation - Case History: An Example of a Conformational Restriction Approach / Frank D. King -- Ch. 15. The Design and Synthesis of Selective Protein Kinase C Inhibitors / Christopher H. Hill -- Ch. 16. Discovery of 1069C - A Novel Synthetic Antitumour Agent with Low Cross-Resistance Potential / Simon T. Hodgson -- Ch. 17. The Design and Biological Properties of 'Dipeptoid' Antagonists / David C. Horwell -- Ch. 18. Migraine Therapy - from Serotonin to Sumatriptan / Peter C. North -- Ch. 19. Drug Development / Jane Ormerod -- App. 1. Summary of Receptor Properties -- App. 2. Summary of Ion Channel Properties -- App. 3. Enzyme Commission Classification of Enzymes -- App. 4. Schematic Representations of Mechanisms of Proteases -- App. 5. Table of Substituent Constant [pi], MR, F, R, and [sigma] -- App. 6. An Example of a Craig Diagram Plot of [sigma] vs. [pi].

App. 7. Summary of Common Routes of Administration -- App. 8. Approximate Conversion Factors for [Delta]log to Ratio -- App. 9. Conversion Factors for Solutions and Dosages: Molar vs. Weight.

All Ages.