TRP channels in drug discovery [[Book] /]
edited by Arpad Szallasi, Tamas Biro.
- New York : Humana Press ; : Springer, c2012-.
- v. <1> : ill. (some col.) ; 26 cm.
- Methods in Pharmacology and Toxicology .
- Methods in pharmacology and toxicology. .
Includes bibliographical references and index.
V. 1. Introduction to TRPs : a quest for novel drug targets / TRP-mediated cytoskeletal reorganization : implications for disease and drug development / TRPA1 in drug discovery / Canonical transient receptor potential channel expression, regulation, and function in vascular and airway diseases / TRPM2 function and potential as a drug target / Ca2+-activated monovalent cation-selective channels TRPM4 and TRPM5 / Emerging role of TRPM7 in the regulation of magnesium homeostasis / TRPM8 channels as potential therapeutic targets for pain, analgesia, and thermoregulation / TRPML channels in function, disease, and prospective therapies / TRPP signaling module : TRPP2/polycystin-1 and TRPP2/PKD1L1 / TRPV1 as a polymodal sensor : potential to discover TRPV1 antagonists selective for specific activating modalities / Nociceptive and nonnociceptive roles of TRPV3 and its "druggability" / TRPV4 and drug discovery / TRP expression and function in the lung airways / Hypoxia-dependent TRP channel function in pulmonary arterial smooth muscle cells / Endotoxin-induced airway inflammation and asthma models / Enhanced cough, animal models / Capsaicin inhalation test in man / TRP channels in the genitourinary tract / Animal models of cystitis / Overactive bladder models / Bernd Nilius -- Chandan Goswami -- Jun Chen, Steve McGaraughty, and Philip R. Kym -- Brij B. Singh, Christina M. Pabelick, and Y.S. Prakash -- Barbara A. Miller -- Barbara Colsoul ... [et al.] -- Vladimir Chubanov ... [et al.] -- David D. McKemy -- David A. Zeevi -- Alexis Hofherr -- Olivier Radresa ... [et al.] -- Sungjae Yoo and Sun Wook Hwang -- Fabien Vincent and Matthew A.J. Duncton -- Alexander Dietrich and Thomas Gudermann -- Beate Fuchs ... [et al.] -- Zsuzsanna Helyes and Zsofia Hajna -- Raffaele Gatti ... [et al.] -- Eva Millqvist -- Ana Charrua and Francisco Cruz -- Celia D. Cruz and Antonio Avelino -- Roberto Soler ... [et al.].