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050		4	_aRA1195 _b.W665 2003
082	0	4	_a615.9 _221
084			_a615.9 _bWG
090			_aRA1211 _i.W66 2003
100	1		_aWoolley, Adam.
245	1	2	_aA guide to practical toxicology _h[Book :] _bevaluation, prediction and risk / _cAdam Woolley.
260			_aBoca Raton, Fla. : _bCRC Press, _cc2003.
300			_axii, 319 p. : _bill. ; _c24 cm.
504			_aIncludes bibliographical references (p. [311]-312) and index.
505	0	0	_tList of illustrations -- _tPreface -- _tAcknowledgements -- _g1. _tIntroduction to toxicology : the necessity of measurement -- _g2. _tNormality : definition and maintenance -- _g3. _tDetermination of toxicity : basic principles -- _g4. _tDetermination of toxicity in in vitro -- _g5. _tDetermination : general and reproductive toxicology -- _g6. _tdetermination : genotoxicity and carcinogenicity -- _g7. _tDeterminism : irritation and sensitisation -- _g8. _tDetermination : environmental toxicology and epidemiology -- _g9. _tInterpretation -- _g10. _tPrediction of hazard -- _g11. _tBackground to risk due to toxicity -- _g12. _tRisk assessment in practice and setting exposure limits -- _g13. _tRisk assessment and management in the workplace -- _g14. _tRisk assessment : carcinogenicity; the environment; evolution and overview of risk assessment -- _g15. The _tfuture of toxicity testing -- _tAppendix : useful websites -- _tSelect glossary -- _tNotes -- _tBibliography -- _tIndex.
520			_aToxicology is a means to an important end: safety. The effective toxicologist begins with this in mind, and uses a clear understanding of safety as a relative concept, together with a rational view of the current safety evaluation paradigm to direct their work. Too often this approach is ignored or discouraged by traditional practice. This lucid, readable book encourages both experienced toxicologists, and those in training, to place toxicological investigation in such a framework. It looks at the importance of toxicological normality, reviews toxicity testing methods, and explores new and "alternative" methods of safety evaluation. The interpretation of toxicity findings in individual studies and data packages and the prediction of human-relevant hazards are reviewed, followed by an introduction to risk and how we perceive and assess risk in the light of known hazards and the probability of their occurrence. The final stage of the toxicological process - risk assessment and management - is reviewed with particular reference to the work place. The book is suitable for professional and student toxicologists as well as those from outside the field who require some knowledge of toxicological method and interpretation, for instance in occupational hygiene or medicine and veterinary surgery. - Back cover.
521			_aAll Ages.
650		0	_aToxicology.
650		0	_aChemical models.
700	1		_aWoolley, Adam.
938			_aBaker & Taylor _bBKTY _c64.95 _d64.95 _i0748409238 _n0004101602 _sactive
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