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_i.W66 2003
100 1 _aWoolley, Adam.
245 1 2 _aA guide to practical toxicology
_h[Book :]
_bevaluation, prediction and risk /
_cAdam Woolley.
260 _aBoca Raton, Fla. :
_bCRC Press,
_cc2003.
300 _axii, 319 p. :
_bill. ;
_c24 cm.
504 _aIncludes bibliographical references (p. [311]-312) and index.
505 0 0 _tList of illustrations --
_tPreface --
_tAcknowledgements --
_g1.
_tIntroduction to toxicology : the necessity of measurement --
_g2.
_tNormality : definition and maintenance --
_g3.
_tDetermination of toxicity : basic principles --
_g4.
_tDetermination of toxicity in in vitro --
_g5.
_tDetermination : general and reproductive toxicology --
_g6.
_tdetermination : genotoxicity and carcinogenicity --
_g7.
_tDeterminism : irritation and sensitisation --
_g8.
_tDetermination : environmental toxicology and epidemiology --
_g9.
_tInterpretation --
_g10.
_tPrediction of hazard --
_g11.
_tBackground to risk due to toxicity --
_g12.
_tRisk assessment in practice and setting exposure limits --
_g13.
_tRisk assessment and management in the workplace --
_g14.
_tRisk assessment : carcinogenicity; the environment; evolution and overview of risk assessment --
_g15. The
_tfuture of toxicity testing --
_tAppendix : useful websites --
_tSelect glossary --
_tNotes --
_tBibliography --
_tIndex.
520 _aToxicology is a means to an important end: safety. The effective toxicologist begins with this in mind, and uses a clear understanding of safety as a relative concept, together with a rational view of the current safety evaluation paradigm to direct their work. Too often this approach is ignored or discouraged by traditional practice. This lucid, readable book encourages both experienced toxicologists, and those in training, to place toxicological investigation in such a framework. It looks at the importance of toxicological normality, reviews toxicity testing methods, and explores new and "alternative" methods of safety evaluation. The interpretation of toxicity findings in individual studies and data packages and the prediction of human-relevant hazards are reviewed, followed by an introduction to risk and how we perceive and assess risk in the light of known hazards and the probability of their occurrence. The final stage of the toxicological process - risk assessment and management - is reviewed with particular reference to the work place. The book is suitable for professional and student toxicologists as well as those from outside the field who require some knowledge of toxicological method and interpretation, for instance in occupational hygiene or medicine and veterinary surgery. - Back cover.
521 _aAll Ages.
650 0 _aToxicology.
650 0 _aChemical models.
700 1 _aWoolley, Adam.
938 _aBaker & Taylor
_bBKTY
_c64.95
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