000			03404cam a22004814a 4500
005			20150712005518.0
008			060420s2006 000 0 eng d
008			031209s2004 dcua bf 001 0 eng
010			_a 2003026662
020			_a1582120544
035			_a(DNLM)101200056
040			_aDNLM/DLC _cDLC _dDLC
042			_apcc
050	0	0	_aRM301.5 _b.R57 2004
060	1	0	_aQV 39 _bR612h 2004
082	0	0	_a615.7 _222
084			_a615.7 _bR B
100	1		_aRitschel, W. A. _q(Wolfgang A.).
245	1	0	_aHandbook of basic pharmacokinetics-- including clinical applications _h[Book /] _cWolfgang A. Ritschel, Gregory L. Kearns.
250			_a6th ed.
260			_aWashington, D.C. : _bAmerican Pharmacists Association, _cc2004.
300			_axii, 432 p. : _bill. ; _c26 cm.
504			_aIncludes bibliographical references and index.
505	0		_aDefinitions and glossary -- The LADMER system: liberation, absorption, distribution, metabolism, elimination, and response -- Organs, tissues, cells, and organelles -- Cell membranes -- Drug-receptor interactions -- Absorption/transport mechanisms -- pKa and degree of ionization -- Lipid/water partition coefficient -- Physicochemical factors altering biological performance of drugs -- Biopharmaceutical data of the gastrointestinal tract -- Fluid compartments and circulatory system -- Binding of drugs to biological material -- Drug biotransformation -- Compartment models -- Determination of rate constants -- Volume of distribution and distribution coefficient -- Excretion and clearance of drugs -- Urinary and biliary recycling.
505	0		_aCumulative urinary excretion -- Area under the blood level-time curve -- Pharmacokinetics of single dose administration -- Pharmacokinetics of multiple dosing -- Compartment model independent analysis -- Pediatric pharmacokinetics -- Drug dosage in elderly patients -- Drug dosage in obese patients -- Drug disposition in pregnancy -- Dosage regimen design -- Drug monitoring and dosage adjustment -- Physiological and pathological factors influencing drug response -- First dosage size in man -- Forensic pharmacokinetics -- Nonlinear pharmacokinetics -- Curve fitting -- Correlation of clinical response with drug disposition -- Bioavailability and bioequivalence -- Body surface areas -- Extracorporeal methods of drug removal -- Pharmacogenetics and pharmacogenomics.
521			_aAll Ages.
650		0	_aPharmacokinetics _vHandbooks, manuals, etc.
650		0	_aClinical pharmacology _vHandbooks, manuals, etc.
650	1	2	_aPharmacokinetics _vHandbooks.
700	1		_aKearns, Gregory L.
710	2		_aAmerican Pharmaceutical Association.
856	4	1	_3Table of contents _uhttp://www.loc.gov/catdir/toc/ecip0412/2003026662.html
856	4	2	_3Publisher description _uhttp://www.loc.gov/catdir/description/mh041/2003026662.html
856	4	2	_3Book review (E-STREAMS) _uhttp://www.e-streams.com/es0712/es0712_3810.html
906			_a7 _bcbc _corignew _d1 _eecip _f20 _gy-gencatlg
925	0		_aacquire _b1 shelf copy _xpolicy default
901			_aPrev. ed. LCCN 98043913
955			_aNLM _ajc00 2003-12-10 to jc02 _djc02 2003-12-10 to technician _ejc03 2003-12-10 to Dewey _aaa01 2003-12-10 _aps05 2004-06-09 1 copy rec'd., to CIP ver. _fjc41 2004-06-14; _gjc13 2004-06-18 to BCCD
985			_aNLMCIP _d2003-12-10
001			0000024782
003			0000
942			_cBK
999			_c53927 _d53927