000			02540nam a22002417a 4500
999			_c59348 _d59348
008			180912s2018 ua ||||g bm|| 00| 0 eng d
040			_cSOUL
041			_aara _heng
082	4	0	_221 _a572 _bG P
100		1	_94552 _aMuhamad, Suzan Shawky Abuel-kasem.
245	0	1	_aBiochemical Effects of chromium, Selenium and Zinc Elements on Experimentally Diabetic Rats / _cSuzan Shawky Abuel-kasem Muhamad ; Supervised by Samy Ahmed Abd El Aziz, Hassan Abdel-Halim Amer, Ismail Ibrahim Hegazy, Mohamed Abdulla Hussein.
246	0	3	_aالتأثيرات الكيميائية الحيوية لعناصر الكروم والسلينيوم والزنك على الفئران المصابة بداء السكري تجريبيأ
260			_aCairo : _bCairo University _c2018.
300			_a213 p. : _c26 cm.
500			_aThesis (Ph.D.) - Cairo University. Faculty of Veterinary Medicine. Department of Biochemistry and Chemistry of Nutrition.
504			_aIncludes bibliographical references.
520			_aThe present work was done to elucidate the possible protective and antioxidant effect of chromium chloride (CrCl) (500 mg/k.g.), sodium selenite (SeNa) (1.5 mg/k.g.) and Zinc sulphate (ZnSO4) (54 mg/k.g.) supplementation in streptozotocin induced diabetic rats. Oral administration of both Cr and Zn as well as intraperitoneal injection of Se at concentrations of 500, 54 and 1.5 mg/kg b.w. daily, respectively for 8 weeks showed a significant decrease in fasting blood glucose, total cholesterol (TC), triacylglycerols (TG), low density lipoprotein (LDL-C) and thiobarbituric acid reactive substances. The treatment also resulted in a significant increase in plasma C-peptide, blood reduced glutathione (GSH) and superoxide dismutase (SOD) as well as gene expression of heart glucose transporter 4 (GLUT4) of diabetic rats. Also, the results clearly suggest that the trace elements treated groups may effectively normalize the body weight as well as high density lipoprotein (HDL-C) in streptozotocin induced-diabetes. The trace elements exerted rapid protective effects against lipid peroxidation by scavenging of free radicals there by reducing the risk of diabetic complications. The effect was more pronounced by Cr supplementation as compared with Se and Zn supplementation.
546			_aText in English, abstracts in English and Arabic.
650		4	_94554 _aTrace elements.
700			_94555 _aAmer, Hassan Abdel-Halim, _eSupervisor
700			_94556 _aAbd El Aziz, Samy Ahmed, _eSupervisor
942			_2ddc _cTHE _iFOP _6FOP