000			02116nam a22002417a 4500
999			_c59351 _d59351
008			180912s2018 ua a|||g bm|| 00| 0 eng d
040			_cSOUL
041			_aeng
082	0	4	_221 _a615.1 _bR D
100	1		_94566 _aRagab, Esraa Zakaria Mohammed
245	1	0	_aDesign, Synthesis and Molecular Modeling Study of Some Thiazolidinone Derivatives as NS5B Polymerase inhibitors / _cEsraa Zakaria Mohammed Ragab ; Supervised by Farghaly Abd-El Hamed Omar, Ghaneya Sayed Hassan, Hanan Hanna Georgey.
246	0	1	_a تصميم وتشييد ودراسة النمذجة الجزيئية لبعض مشتقات الثيازوليدينون كمثبطات لإنزيم البوليمريز
260			_aCairo : _bCairo University, _c2018.
300			_a182p. : _bill. ; _c26 cm. _e+CD.
500			_aThesis (M.Sc.) – Cairo University. Faculty of Pharmacy. Department of Pharmaceutical Chemistry.
504			_aIncludes bibliographical references.
520			_a) Hepatitis C virus (HCV) infection is a major global health challenge; it is estimated that more than 80 million people are chronically infected worldwide, 3–4 million new infections and 350 000 deaths occurring each year because of HCV-related complications. This thesis deals with the design and synthesis of some thiazolidinone derivatives to be evaluated as HCV-NS5B polymerase allosteric inhibitors. In addition, the anti-HCV activity was carried out for the new derivatives using a highly permissive subclone of the human hepatoma cell line Huh-7.5. Molecular docking studies were carried out to predict the possible binding mode of the newly synthesized compounds with HCV-NS5B polymerase to study their interaction with the enzyme key amino acids in a trial to explain their observed activity. Furthermore, key molecular characteristics were calculated to assess their drug-likeness potentia
546			_aText in English, abstracts in English and Arabic.
650	1	4	_93833 _aChemistry, Pharmaceutical
700			_94568 _aGeorgey, Hanan Hanna _eSupervisor
700			_94569 _aHassan, Ghaneya Sayed _eSupervisor
942			_2ddc _cTHE _iFOP _6FOP