000			02855nam a22002537a 4500
999			_c59395 _d59395
008			180910s2014 ua ||||g b|| 00| 0 eng d
040			_cSOUL
041			_aeng _hara
082	4	0	_221 _a617.632 _bA S
100		1	_94696 _aShehab El-Din, Wessam Ibrahim.
245	0	1	_aAntibacterial Effect of Metronidazole Nanoparticles on Porphyromonas Gingivalis in Vitro / _cWessam Ibrahim Shehab El-Din ; Supervised by Azza Ezz Elarab, Ashraf Soror, Enas El-Gendy.
246	0	3	_aتأثير الجسيمات النانونية للمترونيدازول كمضاد للبكتيريا على البورفيروموناس جنجيفالس فى المختبر
260			_aCairo : _b Cairo University. Faculty Of Oral and Dental Medicine. Department Of Oral Medicine and Periodontology. _c2014.
300			_avi, 2, 116 Leaves : _c30 cm. _bill. ;
500			_aThesis (M.Sc.) - Cairo University. Faculty Of Oral and Dental Medicine. Department Of Fixed Prosthodontics.
504			_aIncludes bibliographical references.
520			_aBackground & Objective: Metronidazole has played an important role in anaerobic-related infections. It is used clinically to treat gingivitis, acute necrotizing ulcerative gingivitis, chronic periodontitis and aggressive periodontitis. The newly used nanoparticles loaded with the antibiotics have been introduced in the treatment of many infections. The aim of the present study was to compare between the antibacterial effect of silver nanoparticles, metronidazole and metronidazole carried on silver nanoparticles on Porphyromonas Gingivalis (P.gingivalis) in vitro. Materials and Methods: Minimal inhibitory concentration (MIC) for the silver nanoparticles, metronidazole and the combined use of nanoparticles and metronidazole were determined. Tube dilution methods were performed and weighted in an analytical balance. Results: metronidazole loaded on Silver Nanoparticles was the most efficacious with a MIC of 0.0625 μg/ml while MIC was 0.125 µg/ml for metronidazole and 1 μg/ml for silver nanoparticles. In group III (metronidazole loaded on Silver Nanoparticles) the reduction in number of P.gingivalis was significantly greater than two other groups. Conclusion: Silver nanoparticles could have a synergistic effect with metronidazole, controlled release of metronidazole increases its effect in metronidazole loaded on silver nanoparticles group and metronidazole has an effective antimicrobial activity compared to silver nanoparticles at low concentration.
546			_aText in English, abstract in English & Arabic.
650		4	_94697 _aSurgery, Oral.
700			_94698 _aSoror, Ashraf, _eSupervisor
700			_94699 _aEl-Gendy, Enas, _eSupervisor
710	2		_aCairo University. _bFaculty Of Oral and Dental Medicine. _bDepartment Of Oral Medicine and Periodontology.
942			_2ddc _cTHE _iFOD _6FOD