000			03149nam a22002417a 4500
999			_c59426 _d59426
008			181226s2016 ua a|||g bm|| 00| 0 eng d
040			_cSOUL
041			_aara _heng
082	0	4	_221 _a572 _bI M
100	1		_94820 _aIbrahim, Shaymaa Galal.
245	1	0	_aModulation Of Some Renal Pathological Consequences In Type-2 Diabetic Rats By A Glucagon-Like Peptide Receptor Agonis / _cShaymaa Galal Ibrahim ; Supervised by Tarek K. Motawi, Hanan M. Abd El-Gawad, Sherine Maher Rizk.
246	0	3	_aتعديل بعض التبعات المرضية الكلوية في مرض السكرى النوع الثانى في الجرذان بواسطة ناهض لمستقبلات الببتيد شبيه الجلوكاجون
260			_aCairo : _bCairo University. Faculty of Pharmacy. Department of Biochemistry _c2016..
300			_ax, 4, 204p. : _bill. ; _c27 cm + _e1 CD.
500			_aThesis (M.Sc.) – Cairo University. Faculty of Pharmacy. Department of Biochemistry.
504			_aIncludes bibliographical references.
520			_aDiabetic nephropathy (DN) is one of the most serious complications of diabetes mellitus. Our study aims to demonstrate the effectiveness of exenatide, glucagon like peptide-1 receptor agonist, on insulin release and renal functions in type 2 diabetes mellitus (T2DM) rats enduring DN. T2DM was induced by single streptozotocin (STZ) injection (40 mg/kg, i.p.) followed by high fat diet (HFD) for 10 weeks. Male wistar-albino rats were randomly divided into three groups: a normal control group, a HFD-STZ induced DN model group, and a DN plus exenatide (10 µg/kg/day, i.p.) treatment group. Animals were monitored by periodic biochemical testing of fasting serum glucose (FSG), cystatin-C, creatinine and urinary protein levels. At the end of the study (10 weeks) serum total nitrite/nitrate (NOx), adiponectin, C-peptide and amylase activity were investigated. Renal total triglycerides; hydroxy proline (HP), and DNA fragmentation were estimated, as well as renal enzymatic activity and mRNA expression level of glucose-6-phosphatase. Exenatide showed significant reduction in FSG, serum creatinine, cystatin- C, and urinary protein levels in diabetic rats. It favored increased serum NOx, serum adiponectin as well as C-peptide which reflects improving in insulin sensitivity and release respectively. Further, exenatide diminished renal DNA fragmentation, decreased renal triglyceride, HP contents, and glucose-6-phosphatase enzyme activity and expression levels in diabetic rats. Our data donate further credence for the effectiveness of exenatide against diabetic renal complications, through different aspects including reduction of renal DNA fragmentation and gluconeogenesis in addition to the previously reported mechanisms. Keywords: Diabetic nephropahy; exenatide; streptozotocin; high fat diet; gluconeogenesis; apoptosis.
546			_aText in English, abstracts in English and Arabic.
650	4	0	_91617 _aBiochemistry.
700	1		_94821 _aRizk, Sherine Maher, _esupervisor
710	2		_aCairo University. _bFaculty of Pharmacy. _bDepartment of Biochemistry.
942			_2ddc _cTHE _iFOM _6FOM