Design, Synthesis and Molecular Modeling Study of Some Thiazolidinone Derivatives as NS5B Polymerase inhibitors / Esraa Zakaria Mohammed Ragab ; Supervised by Farghaly Abd-El Hamed Omar, Ghaneya Sayed Hassan, Hanan Hanna Georgey.
Von: Ragab, Esraa Zakaria Mohammed
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Mitwirkende(r): Georgey, Hanan Hanna [Supervisor] | Hassan, Ghaneya Sayed [Supervisor].
Materialtyp: 
BuchVerlag: Cairo : Cairo University, 2018Beschreibung: 182p. : ill. ; 26 cm. +CD.Weitere Titel: تصميم وتشييد ودراسة النمذجة الجزيئية لبعض مشتقات الثيازوليدينون كمثبطات لإنزيم البوليمريز.Schlagwörter: Chemistry, PharmaceuticalDDC-Klassifikation: 615.1 Zusammenfassung: ) Hepatitis C virus (HCV) infection is a major global health challenge; it is estimated that more than 80 million people are chronically infected worldwide, 3–4 million new infections and 350 000 deaths occurring each year because of HCV-related complications.
This thesis deals with the design and synthesis of some thiazolidinone derivatives to be evaluated as HCV-NS5B polymerase allosteric inhibitors. In addition, the anti-HCV activity was carried out for the new derivatives using a highly permissive subclone of the human hepatoma cell line Huh-7.5. Molecular docking studies were carried out to predict the possible binding mode of the newly synthesized compounds with HCV-NS5B polymerase to study their interaction with the enzyme key amino acids in a trial to explain their observed activity. Furthermore, key molecular characteristics were calculated to assess their drug-likeness potentia
| Medientyp | Aktueller Standort | Sammlung | Signatur | Exemplarnr. | Status | Fälligkeitsdatum |
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Theses
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6october 1208 | Default | 615.1 R D (Regal durchstöbern) | 1 | Verfügbar |
Thesis (M.Sc.) – Cairo University. Faculty of Pharmacy. Department of Pharmaceutical Chemistry.
Includes bibliographical references.
) Hepatitis C virus (HCV) infection is a major global health challenge; it is estimated that more than 80 million people are chronically infected worldwide, 3–4 million new infections and 350 000 deaths occurring each year because of HCV-related complications.
This thesis deals with the design and synthesis of some thiazolidinone derivatives to be evaluated as HCV-NS5B polymerase allosteric inhibitors. In addition, the anti-HCV activity was carried out for the new derivatives using a highly permissive subclone of the human hepatoma cell line Huh-7.5. Molecular docking studies were carried out to predict the possible binding mode of the newly synthesized compounds with HCV-NS5B polymerase to study their interaction with the enzyme key amino acids in a trial to explain their observed activity. Furthermore, key molecular characteristics were calculated to assess their drug-likeness potentia
Text in English, abstracts in English and Arabic.
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